SYNTHESIS OF N-ARYLPIPERAZINES FROM ARYL HALIDES AND PIPERAZINE UNDERA PALLADIUM TRI-TERT-BUTYLPHOSPHINE CATALYST

Authors
NISHIYAMA M YAMAMOTO T KOIE Y
Citation
M. Nishiyama et al., SYNTHESIS OF N-ARYLPIPERAZINES FROM ARYL HALIDES AND PIPERAZINE UNDERA PALLADIUM TRI-TERT-BUTYLPHOSPHINE CATALYST, Tetrahedron letters, 39(7), 1998, pp. 617-620
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
7
Year of publication
1998
Pages
617 - 620
Database
ISI
SICI code
0040-4039(1998)39:7<617:SONFAH>2.0.ZU;2-X
Abstract
A Pd/P(t-Bu)(3) catalyst system has revealed very high activity and se lectivity for the amination of N-(hetero)aryl halides with unprotected piperazine. A wide variety of N-(hetero)arylpiperazines could be prep ared using this catalyst. Turnover numbers up to 6400mol/mol have been obtained. (C) 1998 Elsevier Science Ltd. All rights reserved.