MATHEMATICAL-MODELING OF DEPOSITION AND DISPOSITION OF DRUGS ADMINISTERED VIA THE NOSE

This articles reviews the mathematical models of deposition and dispos ition of drugs administered into the human nasal cavity for systemic a ctivity. The modeling of the disposition kinetics includes drug releas e from carriers, translocation within the nasal cavity and into the ga strointestinal tract, drug decomposition, and drug absorption during t he transit through the nose and the gastrointestinal tract. The uses o f such mathematical models for design and analysis of nasal delivery s ystems are illustrated, with particular reference to the new therapeut ic materials and excipients. (C) 1998 Elsevier Science B.V.