THE HUMAN GLUTAMATE-RECEPTOR DELTA-2 GENE (GRID2) MAPS TO CHROMOSOME 4Q22

We isolated the human glutamate receptor delta 2 (GRID2) gene, which h as 97.0% identity in amino acid sequence to the mouse glutamate recept or delta 2 (Grid2) gene. We subsequently mapped this gene to human chr omosome 4q22 by radiation hybrid mapping and by hybridization to two o verlapping human yeast artificial chromosomes that are located in 4q22 . The Grid2 gene, which is mutated in lurcher (Lc) mice, maps to mouse chromosome 6. Thus, the mapping of the GRID2 gene to human chromosome 4q22 confirms and refines a region of synteny between mouse and human genomes. (C) 1998 Academic Press.