We isolated the human glutamate receptor delta 2 (GRID2) gene, which h
as 97.0% identity in amino acid sequence to the mouse glutamate recept
or delta 2 (Grid2) gene. We subsequently mapped this gene to human chr
omosome 4q22 by radiation hybrid mapping and by hybridization to two o
verlapping human yeast artificial chromosomes that are located in 4q22
. The Grid2 gene, which is mutated in lurcher (Lc) mice, maps to mouse
chromosome 6. Thus, the mapping of the GRID2 gene to human chromosome
4q22 confirms and refines a region of synteny between mouse and human
genomes. (C) 1998 Academic Press.