ADENOSINE RECEPTORS IN THE CARDIOVASCULAR-SYSTEM

Authors
Citation
Ra. Olsson, ADENOSINE RECEPTORS IN THE CARDIOVASCULAR-SYSTEM, Drug development research, 39(3-4), 1996, pp. 301-307
Citations number
83
Categorie Soggetti
Chemistry Medicinal","Pharmacology & Pharmacy
Journal title
ISSN journal
02724391
Volume
39
Issue
3-4
Year of publication
1996
Pages
301 - 307
Database
ISI
SICI code
0272-4391(1996)39:3-4<301:ARITC>2.0.ZU;2-O
Abstract
The remarkably comprehensive qualitative description of the cardiovasc ular actions of adenosine by Drury and Szent-Gyorgyi [(1929): J Physio l 6:213-237] serves as a framework for current research on the cellula r and molecular mechanisms of those actions. This article reviews eigh t areas in this field that have advanced significantly during the past 5 years: (1) the kinds of potassium channels coupled to the cardiomyo cyte A(1)AR; (2) the mechanism of the ''anti-adrenergic'' action of ad enosine; (3) the role of adenosine in angina pectoris; (4) the role of adenosine in ischemic preconditioning; (5) the occurrence of A(2)AR i n ventricular myocytes; (6) evidence for A(1)-, A(2)A-, A(2B)- and A(3 )ARs in blood vessels; (7) the role of nitric oxide in adenosine-initi ated vasodilation; and (8) the effect of adenosine on microvascular pe rmeability. In some areas, solid evidence has defined a particular mec hanism; in others, the evidence is as yet incomplete. (C) 1997 Wiley-L iss, Inc.