TRANSLOCATION(8-20-21)(Q22-Q13-Q22) IN ACUTE MYELOBLASTIC-LEUKEMIA WITH MATURATION - A VARIANT FORM OF T(8-21)

Authors
WONG KF KWONG YL SO CC
Citation
Kf. Wong et al., TRANSLOCATION(8-20-21)(Q22-Q13-Q22) IN ACUTE MYELOBLASTIC-LEUKEMIA WITH MATURATION - A VARIANT FORM OF T(8-21), Cancer genetics and cytogenetics, 101(1), 1998, pp. 39-41
Citations number
8
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Cancer genetics and cytogenetics → ACNP
ISSN journal
01654608
Volume
101
Issue
1
Year of publication
1998
Pages
39 - 41
Database
ISI
SICI code
0165-4608(1998)101:1<39:TIAMW>2.0.ZU;2-W
Abstract
A 39-year-old man was diagnosed as having acute myeloblastic leukemia with maturation (AML-M2). Cytogenetic studies revealed 45,X,-Y,t(8;20) (q22;q13)(21)/46,XY[3]. Molecular analysis of the marrow mononuclear c ells by reverse transcription-polymerase chain reaction with nested AM L1 and ETO primers showed amplification of the AML1/ETO fusion transcr ipt, thus confirming that the chromosomal aberration was in fact a mas ked t(8;21), i.e., variant t(8;20;21)(q22;q13;q22). (C) Elsevier Scien ce Inc., 1998.