TRISOMY-1 IN A CANINE ACUTE-LEUKEMIA INDICATING THE PATHOGENETIC IMPORTANCE OF POLYSOMY-1 IN LEUKEMIAS OF THE DOG

We report on a canine acute myeloid leukemia showing a trisomy 1 and a t(X;8) as clonal cytogenetic abnormalities. Comparing these results w ith similar cases of canine leukemias reported in the literature one r ealizes that trisomy 1 is a recurrent cytogenetic finding in canine ac ute leukemia. Trisomy 1 may be a specific anomaly associated with eith er etiology or progression of this disease. As with comparable human n eoplasms, cytogenetic investigations could be of diagnostic and progno stic significance for canine hematopoietic diseases. Moreover, as tris omies are recurrent cytogenetic findings in human leukemias, as well, comparative gene mapping in future studies may help to focus the etiol ogic basis of the disease to particular chromosomal segments instead o f whole chromosomes. (C) Elsevier Science Inc., 1998.