PRETIBIAL EPIDERMOLYSIS-BULLOSA - AN UNCO MMON CASE OF A SIMPLEX EPIDERMOLYSIS-BULLOSA

Introduction. Pretibial epidermolysis bullosa had been classified as a rare localized form of autosomal dominant dystrophic epidermolysis bu llosa. Observation. We report a sporadic case of a patient suffering f rom bullous lesions induced by minor trauma on pretibial skin. The les ions healed with atrophic scars. No milia formation was observed. The mapping of dermoepidermal junction by LH 7:2 and GB3 monoclonal antibo dies was normal. By electron microscopy, numerous perinuclear vacuoles were observed and the cleavage occured within the basal keratinocytes . Discusion. This patient had clinical features in accordance with a d iagnosis of pretibial epidermolysis bullosa. However, in contrast to p revious case reports, the ultrastructural pattern was this of an epide rmolysis bullosa of simplex type.