Purpose: To assess the frequency and prognosis of skin recurrences aft
er breast-conserving therapy (BCT) compared with other breast recurren
ces. Materials and Methods: From 1968 to 1986, 1,624 patients with uni
lateral stage I or II breast cancer treated with BCT at the Joint Cent
er for Radiation Therapy (Boston, MA) underwent gross tumor excision a
nd received a dose of greater than or equal to 60 Gy to the tumor bed.
Skin recurrences (58) were defined as breast recurrences without asso
ciated parenchymal disease. An invasive breast recurrence with any par
enchymal disease noted clinically or radiographically was scored as an
other breast recurrence (OBR). Median follow-up for survivors was 137
months. Results: SR represented 8% (18 of 229) of all breast recurren
ces and occurred in 1.1% of all patients. The outcome after local recu
rrence was different for patients with SR and invasive OBR. Patients w
ith SR more frequently had uncontrolled local failure (50%; 9 of 18) t
han did patients with OBR (14%; 26 of 188) (P = .0007). Forty-four per
cent (8 of 18) of patients with SR had distant metastasis simultaneous
ly or within 2 months of the recurrence compared with 5% (9 of 188) of
invasive OBR patients (P < .0001). for patients without distant metas
tasis at the time of recurrence, the 5-year actuarial rate of developm
ent of distant metastasis was 60% for SR patients compared with 39% fo
r invasive OBR patients (P = .07), and the corresponding 5-year actuar
ial survival rates beyond the time of local failure were 51% and 79%,
respectively (P = .06). Conclusion: In contrast to other types of inva
sive breast recurrence after breast-conserving therapy, skin recurrenc
es are rare and are associated with a significantly higher rate of dis
tant metastasis and uncontrolled local disease as well as a lower rate
of survival. (C) 1998 by American Society of Clinical Oncology.