This article addresses the ubiquitous nature of uncertainty in industr
ial hygiene-related risk assessment and defines two basic types of unc
ertainly: natural variability and a basic lack of knowledge. A relativ
ely simple physical-chemical modeling example is provided as an illust
ration in which uncertainty and sensitivity are described using two me
thods, a conventional technique and a readily available and user-frien
dly computer simulation software. The need for and Value of monitoring
data for validation and as a ''reality check'' is emphasized.