PRONASE CATALYZED PEPTIDE SYNTHESES

A mixture of proteases from Streptomyces griseus (pronase), displaying a very broad substrate tolerance in the hydrolysis of peptides, has b een studied for the first time systematically regarding their substrat e specificity in peptide synthesis, It is demonstrated that pronase ca n be employed successfully for the formation of dipeptides with yields up to 95%, Pronase has also been employed successfully as catalyst fo r the enzyme assisted synthesis of a hexapeptide.