PREPARATION OF 4-SUBSTITUTED 10-ETHYLPHENOTHIAZINES

Authors
EBDRUP S JENSEN MS VEDSO P
Citation
S. Ebdrup et al., PREPARATION OF 4-SUBSTITUTED 10-ETHYLPHENOTHIAZINES, Journal of the Chemical Society. Perkin transactions. I, (2), 1998, pp. 351-354
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
2
Year of publication
1998
Pages
351 - 354
Database
ISI
SICI code
0300-922X(1998):2<351:PO41>2.0.ZU;2-O
Abstract
Under appropriate reaction conditions 10-ethylphenothiazine 1 undergoe s lithiation at C-4 using an excess of sec-butyllithium-N,N,N',N'-tetr amethyl in diethyl ether, Reaction of the lithiated intermediate with a variety of carbon, halogen, sulfur and silicon electrophiles affords several new 4-substituted 10-ethylphenothiazines 3a-i in good yields.