S. Cicchi et al., NEW ENANTIOMERICALLY PURE OLIGOMERIC MACROCYCLES BASED ON A 3,4-DIHYDROXYPYRROLIDINE NUCLEUS, Journal of the Chemical Society. Perkin transactions. I, (2), 1998, pp. 367-370
(3S,4S)-N-Benzyl-3,4-dihydroxypyrrolidine 1 has been used as a buildin
g block for new enantiopure macrocyclic polyesters, Two different synt
hetic approaches are presented leading to complementary results, The s
tructure of the macrocycles synthesized has been confirmed by NMR spec
troscopy and FAB mass spectrometry, and that for dimer 8 has been conf
irmed by X-ray analysis.