FABRICATION OF MICROSCOPIC BIOSENSOR ARRAYS WITHOUT MICROSCOPIC ALIGNMENT

Microscopic arrays of biosensors can be formed by patterning chemicall y or biochemically functional groups onto surfaces, e.g., by photolith ography or microprinting. A method of fabrication of microscopic biose nsor arrays is described that has the advantage, compared to the above mentioned methods, of not requiring microscopic alignment: first, sel f-assembled monolayers (SAMs) are spatially selectively removed from g old arrays by electrochemical desorption, then the exposed elements ar e remodified with SAMs formed of different alkanethiolates.