U-INSERTION DELETION-EDITED-SEQUENCE-DATABASE

Uridine insertion/deletion RNA editing posttranscriptional RNA modific ation occurring in the mitochondria of kinetoplastid protozoa. The U-i nsertion/deletion Edited Sequence Database is a compilation of mitocho ndrial genes and edited mRNAs from five kinetoplastid species. It cont ains separate files with the DNA, mRNA (both unedited and edited) and predicted protein sequences, as well as alignments of the Leishmania t arentolae and Trypanosoma brucei protein sequences from edited and une dited genes, The sequence files are in GCG format. A 'map' sequence fi le showing the location of U-deletions, U-insertions and the translate d amino acid sequences is also provided for each gene. Genomic maps fo r each species are also provided with clickable genes, including maxic ircle-encoded gRNAs. Sets of aligned nuclear rRNA sequences from kinet oplastid protozoa are also provided, which were used for phylogenetic reconstructions in an analysis of the origin of RNA editing, The datab ase is available through the World Wide Web as an HTML document at the URL ww.lifesci.ucla.edu/RNA/trypanosome/database.html.