DATABASES AND SOFTWARE FOR THE ANALYSIS OF MUTATIONS IN THE HUMAN P53GENE, HUMAN HPRT GENE AND BOTH THE LACI AND LACZ GENE IN TRANSGENIC RODENTS

We have created databases and software applications for the analysis o f DNA mutations at the human p53 gene, the human hprt gene and both th e rodent transgenic lad and lacZ loci, The databases themselves are st and-alone dBASE files and the software for analysis of the databases r uns on IBM-compatible computers with Microsoft Windows, Each database has a separate software analysis program, The software created for the se databases permit the filtering, ordering, report generation and dis play of information in the database, In addition, a significant number of routines have been developed for the analysis of single base subst itutions, One method of obtaining the databases and software is via th e World Wide Web, Open the following home page with a Web Browser: htt p://sunsite.unc.edu/dnam/mainpage.html. Alternatively, the databases a nd programs are available via public FTP from: anonymous@sunsite.unc.e du. There is no password required to enter the system, The databases a nd software are found beneath the subdirectory: pub/academic/biology/d na-mutations. Two other programs are available at the site, a program for comparison of mutational spectra and a program for entry of mutati onal data into a relational database.