P53 GENE MUTATION - SOFTWARE AND DATABASE

A large number of different mutations in the p53 tumor suppressor gene have been identified in all types of cancer. As of October, 1997, thi s database (http:// perso.curie.fr/tsoussi) contained >7500 mutations. Such a substantial increase since our previous reports should enable epidemiological analyses which were not previously possible. In order to analyse these new data, the UMD software has been improved. A new W eb version of the UMD software enables online analysis of the database . The present report describes various improvements since the last rel ease of the database.