THE ANDROGEN-RECEPTOR-GENE-MUTATIONS-DATABASE

The current version of the androgen receptor (AR) gene mutations datab ase is described, The total number of reported mutations has risen fro m 272 to 309 in the past year, We have expanded the database: (i) by g iving each entry an accession number; (ii) by adding information on th e length of polymorphic polyglutamine (polyGln) and polyglycine (polyG ly) tracts in exon 1; (iii) by adding information on large gene deleti ons; (iv) by providing a direct link with a completely searchable data base (courtesy EMBL-European Bioinformatics Institute), The addition o f the exon 1 polymorphisms is discussed in light of their possible rel evance as markers for predisposition to prostate or brest cancer. The database is also available on the internet (http://www.mcgill.ca/andro gendb/), from EMBL-European Bioinformatics Institute (ftp.ebi.ac.uk/pu b/databases/androgen), or as a Macintosh FilemakerPro or Word file (MC 33@musica.mcgill.ca).