GPCRDB - AN INFORMATION-SYSTEM FOR G-PROTEIN-COUPLED RECEPTORS

The GPCRDB is a G protein-coupled receptor (GPCR) database system aime d at the collection and dissemination of GPCR related data, It holds s equences, mutant data and ligand binding constants as primary (experim ental) data. Computationally derived data such as multiple sequence al ignments, three dimensional models, phylogenetic trees and two dimensi onal visualization tools are added to enhance the database's usefulnes s, The GPCRDB is an EU sponsored project aimed at building a generic m olecular class specific database capable of dealing with highly hetero geneous data. GPCRs were chosen as test molecules because of their eno rmous importance for medical sciences and due to the availability of s o much highly heterogeneous data. The GPCRDB is available via the WWW at http://www.gpcr.org/7tm.