EFFICACY OF TROVAFLOXACIN AGAINST EXPERIMENTAL STAPHYLOCOCCUS-AUREUS ENDOCARDITIS

Trovafloxacin is a new fluoronaphthyridone chemically and functionally related to members of the fluoroquinolone class of antimicrobial agen ts. The in vivo efficacy of the drug was compared with that of vancomy cin by using the rabbit model of left-sided endocarditis. Rabbits infe cted with either a nafcillin-susceptible or -resistant test strain wer e treated with trovafloxacin (13.3 mg/kg of body weight every 12 h) or vancomycin (25 mg/kg of body weight every 8 h) for 4 days. In compari son with untreated controls, both antimicrobial agents effectively cle ared bacteremia and significantly reduced bacterial counts in vegetati ons and tissues of animals infected with either test strain, No resist ance to trovafloxacin emerged in test strains during therapy, We concl ude that in this model trovafloxacin is as efficacious as vancomycin i s and may serve as a viable alternative to vancomycin for use in human s with similar infections.