IN-VITRO ACTIVITIES OF Y-688, A NEW 7-SUBSTITUTED FLUOROQUINOLONE, AGAINST ANAEROBIC-BACTERIA

Authors
MACGOWAN AP BOWKER KE WOOTTON M HOLT HA REEVES DS
Citation
Ap. Macgowan et al., IN-VITRO ACTIVITIES OF Y-688, A NEW 7-SUBSTITUTED FLUOROQUINOLONE, AGAINST ANAEROBIC-BACTERIA, Antimicrobial agents and chemotherapy, 42(2), 1998, pp. 419-424
Citations number
17
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
42
Issue
2
Year of publication
1998
Pages
419 - 424
Database
ISI
SICI code
0066-4804(1998)42:2<419:IAOYAN>2.0.ZU;2-4
Abstract
The in vitro activities of Y-688, a new 7-substituted fluoroquinolone derivative, against 317 nonduplicate anaerobic isolates were determine d. Eighty-five percent of the Bacteroides fragilis group (n = 89) were inhibited by less than or equal to 2 mg of Y-688 per liter, while 78, 100, 89, and 98% of gram-negative bacilli (n = 135), gram-positive co cci (n = 59), and non-spore-forming (n = 58) and spore-forming (n = 51 ) gram-positive bacilli, respectively, were inhibited by less than or equal to 1 mg of Y-688 per liter.