PHARMACOKINETICS AND INFLAMMATORY FLUID PENETRATION OF CLINAFLOXACIN

A single 200-mg dose of clinafloxacin was given orally to each of nine healthy male volunteers, and the concentrations of the drug were meas ured in plasma, cantharidin-induced inflammatory fluid, and urine over the following 23 h (48 h in the case of urine). The mean maximum conc entration in plasma was 1.34 mu g/ml at a mean time of 1.8 h postdose. The mean maximum concentration in the inflammatory fluid was 1.3 mu g /ml at 3.8 h postdose, The mean elimination half-life of clinafloxacin in plasma was 5.65 h. The overall penetration into the inflammatory f luid was 93.1%, as assessed by determining the ratio of area under the concentration-time curves. Recovery of clinafloxacin in urine was 58. 8% by 24 h and 71.8% by 48 h postdose.