ALTERATIONS IN THE GYRA SUBUNIT OF DNA GYRASE AND THE PARC SUBUNIT OFDNA TOPOISOMERASE-IV ASSOCIATED WITH QUINOLONE RESISTANCE IN ENTEROCOCCUS-FAECALIS

Authors
KANEMATSU E DEGUCHI T YASUDA M KAWAMURA T NISHINO Y KAWADA Y
Citation
E. Kanematsu et al., ALTERATIONS IN THE GYRA SUBUNIT OF DNA GYRASE AND THE PARC SUBUNIT OFDNA TOPOISOMERASE-IV ASSOCIATED WITH QUINOLONE RESISTANCE IN ENTEROCOCCUS-FAECALIS, Antimicrobial agents and chemotherapy, 42(2), 1998, pp. 433-435
Citations number
23
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
42
Issue
2
Year of publication
1998
Pages
433 - 435
Database
ISI
SICI code
0066-4804(1998)42:2<433:AITGSO>2.0.ZU;2-G
Abstract
The gyrA and parC genes of 31 clinical isolates of Enterococcus faecal is, including fluoroquinolone-resistant isolates, were partially seque nced and analyzed for target alterations. Topoisomerase TV may be a pr imary target in E. faecalis, but high-level fluoroquinolone resistance was associated with simultaneous alterations in both GyrA and ParC.