EFFECTS OF ALUMINUM HYDROXIDE AND FAMOTIDINE ON BIOAVAILABILITY OF TOSUFLOXACIN IN HEALTHY-VOLUNTEERS

Authors
MINAMI R NAKAMURA C INOTSUME N NAKANO M
Citation
R. Minami et al., EFFECTS OF ALUMINUM HYDROXIDE AND FAMOTIDINE ON BIOAVAILABILITY OF TOSUFLOXACIN IN HEALTHY-VOLUNTEERS, Antimicrobial agents and chemotherapy, 42(2), 1998, pp. 453-455
Citations number
13
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
42
Issue
2
Year of publication
1998
Pages
453 - 455
Database
ISI
SICI code
0066-4804(1998)42:2<453:EOAHAF>2.0.ZU;2-C
Abstract
This study was designed to determine the influence of aluminum hydroxi de and famotidine on the bioavailability of tosufloxacin. Coadministra tion of aluminum hydroxide reduced the bioavailability of tosufloxacin by 31.6% (P < 0.05). Famotidine did not alter tosufloxacin absorption . To avoid potential treatment failures, the concurrent use of tosuflo xacin and aluminum hydroxide should be avoided altogether.