EFFECTS OF PROBENECID AND CIMETIDINE ON RENAL DISPOSITION OF OFLOXACIN IN RATS

Authors
FOOTE EF HALSTENSON CE
Citation
Ef. Foote et Ce. Halstenson, EFFECTS OF PROBENECID AND CIMETIDINE ON RENAL DISPOSITION OF OFLOXACIN IN RATS, Antimicrobial agents and chemotherapy, 42(2), 1998, pp. 456-458
Citations number
24
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
42
Issue
2
Year of publication
1998
Pages
456 - 458
Database
ISI
SICI code
0066-4804(1998)42:2<456:EOPACO>2.0.ZU;2-N
Abstract
The renal handling of ofloxacin in rats which were given ofloxacin eit her alone or in combination with probenecid or cimetidine was studied. In the presence of cimetidine or probenecid, ofloxacin's total and re nal clearances were reduced and its half-life was prolonged. This sugg ests that ofloxacin is secreted by both the anionic and cationic trans port systems.