CRITICAL IMPORTANCE OF IN-VIVO AMOXICILLIN AND CEFOTAXIME CONCENTRATIONS FOR SYNERGY IN TREATMENT OF EXPERIMENTAL ENTEROCOCCUS-FAECALIS ENDOCARDITIS

Authors
JOINLAMBERT O MAINARDI JL CUVELIER C DAUTREY S FARINOTTI R FANTIN B CARBON C
Citation
O. Joinlambert et al., CRITICAL IMPORTANCE OF IN-VIVO AMOXICILLIN AND CEFOTAXIME CONCENTRATIONS FOR SYNERGY IN TREATMENT OF EXPERIMENTAL ENTEROCOCCUS-FAECALIS ENDOCARDITIS, Antimicrobial agents and chemotherapy, 42(2), 1998, pp. 468-470
Citations number
13
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
42
Issue
2
Year of publication
1998
Pages
468 - 470
Database
ISI
SICI code
0066-4804(1998)42:2<468:CIOIAA>2.0.ZU;2-M
Abstract
The synergy between amoxicillin and cefotaxime against two strains of Enterococcus faecalis (JH2-2 and 6370) in vitro and in rabbit endocard itis was investigated. In vitro synergy was obtained only when amoxici llin concentrations were below the MBC and when cefotaxime concentrati ons were above 1 mu g/ml. No synergy was observed in vivo, because of the short period of time during which these pharmacologic requirements were achieved.