ESTIMATE OF THE FREQUENCY OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PROTEASE INHIBITOR RESISTANCE WITHIN UNSELECTED VIRUS POPULATIONS IN-VITRO

Authors
TUCKER SP STIEBEL TR POTTS KE SMIDT ML BRYANT ML
Citation
Sp. Tucker et al., ESTIMATE OF THE FREQUENCY OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PROTEASE INHIBITOR RESISTANCE WITHIN UNSELECTED VIRUS POPULATIONS IN-VITRO, Antimicrobial agents and chemotherapy, 42(2), 1998, pp. 478-480
Citations number
23
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
42
Issue
2
Year of publication
1998
Pages
478 - 480
Database
ISI
SICI code
0066-4804(1998)42:2<478:EOTFOH>2.0.ZU;2-5
Abstract
The frequency of drug-resistant human immunodeficiency virus type 1 (H IV-1) variants in virus populations not previously exposed to drug was determined in vitro by using HIV-1(RF) and the protease inhibitor SC- 55389A. Two variants,vith single mutations responsible for drug resist ance (V82A and N88S) were quantifiably isolated after only one round o f replication, yielding a crude frequency estimate of at least 1 SC-55 389A-resistant variant per 3.5 x 10(5) wild-type infectious units.