ARACHIDONIC-ACID-SELECTIVE CYTOSOLIC PHOSPHOLIPASE-A2 IS INVOLVED IN GASTRIN-INDUCED AR4-2J-CELL PROLIFERATION

Authors
GHRIB F PYRONNET S BASTIE MJ FAGOTREVURT P PRADAYROL L VAYSSE N
Citation
F. Ghrib et al., ARACHIDONIC-ACID-SELECTIVE CYTOSOLIC PHOSPHOLIPASE-A2 IS INVOLVED IN GASTRIN-INDUCED AR4-2J-CELL PROLIFERATION, International journal of cancer, 75(2), 1998, pp. 239-245
Citations number
28
Categorie Soggetti
Oncology
Journal title
International journal of cancer → ACNP
ISSN journal
00207136
Volume
75
Issue
2
Year of publication
1998
Pages
239 - 245
Database
ISI
SICI code
0020-7136(1998)75:2<239:ACPIII>2.0.ZU;2-G
Abstract
Gastrin/CCKB G protein-coupled receptors have been shown to mediate pr oliferation stimulated by their endogenous ligands. The present study demonstrates the proliferative effect of arachidonic acid on AR4-2J ce lls. Gastrin induces an [H-3]arachidonic-acid release in a dose-depend ent manner. The use of a specific inhibitor of cPLA2, AACOCF3 establis hed the involvement of a cPLA2 in the proliferative effect of gastrin. The results also demonstrate that a cytosolic high-molecular-weight P LA2 is activated by gastrin in AR4-2J cells. (C) 1998 Wiley-Liss, Inc.