A RHINO MUTANT ORIGINATING IN KK MICE

In 1991, several hairless offspring were found in our black haired KK (KK-C) mouse colony. This mutant, provisionally naming KK-rhino mouse was clinicopathologically and histopathologically investigated in a ch ronological manner. KK-rhino has a hairless trait and wrinkled and pim pled skin, which resemble the characteristics of the so-called rhino m ouse. It was presumed from a preliminary mating examination that the t rait of the KK-rhino mutant might be manifested by the [hr(rh)] gene. Other properties of this mutant might be inherited from the maternal K K-C line. KK-rhino mouse is a unique mouse strain which has two quite different traits, ''rhino'' and ''diabetes''.