A NEW THYMINE FREE SYNTHESIS OF THE ANTI-AIDS DRUG D4T VIA REGIO STEREO CONTROLLED BETA-ELIMINATION OF BROMOACETATES/

Authors
CHEN BC QUINLAN SL REID JG SPECTOR RH
Citation
Bc. Chen et al., A NEW THYMINE FREE SYNTHESIS OF THE ANTI-AIDS DRUG D4T VIA REGIO STEREO CONTROLLED BETA-ELIMINATION OF BROMOACETATES/, Tetrahedron letters, 39(8), 1998, pp. 729-732
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
8
Year of publication
1998
Pages
729 - 732
Database
ISI
SICI code
0040-4039(1998)39:8<729:ANTFSO>2.0.ZU;2-2
Abstract
The anti-AIDS drug d4T was prepared without contamination of the nucle oside bond cleaved by-product thymine from the readily available ribon ucleoside 5-methyluridine (1). This was accomplished by using a new st rategy which involved a regio/stereo controlled beta-elimination of tr ans-bromoacetates 6. (C) 1998 Bristol-Myers Squibb Company. Published by Elsevier Science Ltd.