NOVEL SERINE-BASED LINKER FOR THE SOLID-PHASE SYNTHESIS OF ORGANIC-COMPOUNDS

Authors
CHOU YL MORRISSEY MM MOHAN R
Citation
Yl. Chou et al., NOVEL SERINE-BASED LINKER FOR THE SOLID-PHASE SYNTHESIS OF ORGANIC-COMPOUNDS, Tetrahedron letters, 39(8), 1998, pp. 757-760
Citations number
6
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
8
Year of publication
1998
Pages
757 - 760
Database
ISI
SICI code
0040-4039(1998)39:8<757:NSLFTS>2.0.ZU;2-#
Abstract
A novel serine-derived Linker has been developed that allows phenolic templates to be cleaved from the resin with fluoride ion. The linker i s stable to acids such as TFA and bases such as pyrrolidine. The linke r should provide utility in multi-step solid phase organic chemistry p rotocols where both acid and base chemistry is used. (C) 1998 Elsevier Science Ltd. All rights reserved.