We report the synthesis of an original unsymmetrical bismacrocycle bea
ring a carboxylic side-arm. Two different synthetic pathways were inve
stigated, both involving a Schotten-Baumann like reaction. The first r
oute allowed us to obtain a mixture of compounds whilst the second one
was direct and non-ambiguous. (C) 1998 Elsevier Science Ltd. All righ
ts reserved.