A HIGHLY ACID-LABILE SILICON LINKER FOR SOLID-PHASE SYNTHESIS

Authors
HONE ND DAVIES SG DEVEREUX NJ TAYLOR SL BAXTER AD
Citation
Nd. Hone et al., A HIGHLY ACID-LABILE SILICON LINKER FOR SOLID-PHASE SYNTHESIS, Tetrahedron letters, 39(8), 1998, pp. 897-900
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
8
Year of publication
1998
Pages
897 - 900
Database
ISI
SICI code
0040-4039(1998)39:8<897:AHASLF>2.0.ZU;2-E
Abstract
A novel arylsilane based linker has been prepared for the solid phase synthesis of small molecule combinatorial libraries. Efficient cleavag e is achieved using TFA via anchimerically assisted protiodesilylation to yield aromatic products possessing no residual linker functionalit y. (C) 1998 Elsevier Science Ltd. All rights reserved.