COMPARISON OF CARDIAC TROPONIN-T AND CARDIAC TROPONIN-I CONCENTRATIONS IN PERIPHERAL-BLOOD DURING ORCIPRENALINE INDUCED TACHYCARDIA IN RATS

In this study we addressed the question of whether the measurement of the cardiac structure protein cardiac Toponin T (cTnI) in serum is als o able to detect marked myocardial cell damage in rats like cardiac Tr oponin T (cTnT). To answer this question 5 male rats and 5 female rats were injected with orciprenaline to induce myocardial cell damage. Fu rther 5 animals of each sex received physiological saline as control. We could demonstrate that troponin I was rised significantly 6 hours a fter injection in serum as well as cTnT. 24 hours after injection cTnI was elevated on a lower significance level compared to cTnT. All valu es returned to normal 96 hours after the injection. We conclude that c TnI was also able to detect a marked myocardial cell damage in rats bu t we could show that cTnI was elevated on a lower significance level c ompared to cTnT. Furthermore we found that a cTnI increase to at least 4.1 ng/ml is necessary to detect marked myocardial cell injury in thi s rat tachycardia model.