ELECTROANALYSIS AND MECHANISM OF THE REDU CTION OF THE ANTIPSYCHOTIC DRUG TIMELOTEM, ,4A,5-HEXAHYDRO-PYRAZINO[1,2-A][1,4]BENZODIAZEPIN, AT THE DROPPING MERCURY-ELECTRODE

Timelotem (1) is reduced at the dropping mercury electrode over the pH range 1.0-12 in Britton Robinson buffers (BRP) containing 10% methano l as a solubilizer. The drug is reduced over the pH range 1-4 in one w ave (A) with consumption of 2e + 1H(+) and over the range 4-11 in two waves (A(1), A(2)) with consumption of 2 - 3e + 2H(+). The well-define d cathodic wave A is very suitable for analytical purposes, The electr ode reaction is irreversible, The limit of the detection by densing cu rrent polarography is in the range of 2.5.10(-6) mol.l(-1).