EFFICIENCY OF HEMOPERFUSION MATERIALS AT REMOVING THE FUNGAL TOXIN ORELLANINE FROM HUMAN PLASMA

Orellanine is the main toxin of various Cortinarius mushrooms and resp onsible for their nephrotoxicity. The present study was undertaken to estimate the value of haemoperfusion in Cortinarius intoxications. The efficiency of the haemoperfusion materials activated charcoal (DHP-1) and Amberlite XAD 4 resin at removing orellanine from plasma was test ed in an in vitro model. Quantification of the toxin in plasma samples was carried out following a previously reported fluoro-densitometric TLC method. Orellanine is sufficiently bound to both haemoperfusion ma terials, However, the rate of orellanine adsorption was four times hig her on activated charcoal (DHP-1) compared to Amberlite XAD 4 resin.