Food additives have been implicated as aetiological factors in many di
fferent disease states. Concern arose from a suggested link with food
additives and hyperactivity in children. They have also been implicate
d in many other disease states. This perception, often made by parents
on behalf of their children, is not confirmed by double-blind placebo
-controlled challenge studies. The discrepancy between public percepti
on and the true prevalence of food additive reactions is great and thi
s discrepancy between perception and confirmed reactions also exists w
ith food-related symptoms. The discrepancy is much greater in the case
of food additives than in foods. The mechanism of food additive react
ions is not immunological and there is no in vivo or in vitro confirma
tory test. (C) 1997 Elsevier Science B.V.