FRIEDELANE TRITERPENOIDS FROM MAYTENUS-MACROCARPA

A set of friedelane triterpenoids has been isolated from the stem bark exudates of Maytenus macrocarpa. It includes a new friedelan triterpe ne (1), together with the known compounds friedelin, 3-oxo-29-hydraxyf riedelane, 3-oxofriedelan-25-al, and canophyllol. The structures of th ese compounds were elucidated by spectroscopic and chemical evidence. Complete H-1 and C-13 assignments were achieved by 2D NMR spectroscopy . The new compound showed weak activity against aldose reductase. It d id not display antitumor activity against P-388 lymphoid neoplasm, A-5 49 human lung carcinoma, HT-29 human colon carcinoma, or MEL-28 human melanoma cell lines.