IDENTIFICATION OF MAGNOLOL AND HONOKIOL AS ANXIOLYTIC AGENTS IN EXTRACTS OF SAIBOKU-TO, AN ORIENTAL HERBAL MEDICINE

Authors
MARUYAMA Y KURIBARA H MORITA M YUZURIHARA M WEINTRAUB ST
Citation
Y. Maruyama et al., IDENTIFICATION OF MAGNOLOL AND HONOKIOL AS ANXIOLYTIC AGENTS IN EXTRACTS OF SAIBOKU-TO, AN ORIENTAL HERBAL MEDICINE, Journal of natural products, 61(1), 1998, pp. 135-138
Citations number
12
Categorie Soggetti
Chemistry Medicinal","Plant Sciences","Pharmacology & Pharmacy
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
61
Issue
1
Year of publication
1998
Pages
135 - 138
Database
ISI
SICI code
0163-3864(1998)61:1<135:IOMAHA>2.0.ZU;2-J
Abstract
The principal active anxiolytic components in Saiboku-to, an Oriental herbal medicine, have been isolated and identified as magnolol (5,5'-d i-2-propenyl-1,1'-biphenyl-2,2'-diol) and honokiol (3',5-di-2-propenyl -1, 1'-biphenyl-2,4'-diol). Evaluation by means of an elevated plus-ma ze test showed that honokiol was at least 5000 times more potent than Saiboku-to when mice were treated orally for 7 days.