A NEW ANTIPLATELET DIARYLHEPTANOID FROM ALPINIA BLEPHAROCALYX

Authors
DONG H CHEN SX XU HX KADOTA S NAMBA T
Citation
H. Dong et al., A NEW ANTIPLATELET DIARYLHEPTANOID FROM ALPINIA BLEPHAROCALYX, Journal of natural products, 61(1), 1998, pp. 142-144
Citations number
15
Categorie Soggetti
Chemistry Medicinal","Plant Sciences","Pharmacology & Pharmacy
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
61
Issue
1
Year of publication
1998
Pages
142 - 144
Database
ISI
SICI code
0163-3864(1998)61:1<142:ANADFA>2.0.ZU;2-Z
Abstract
A new diarylheptanoid, 1,7-bis(4-hydroxyphenyl)-3-hydroxy-1,3-(1), alo ng with seven other known compounds, were isolated from the seeds of A lpinia blepharocalyx. Of these, compounds 1 and 3 showed strong inhibi tion of collagen-induced, arachidonic acid-induced, and adenosine diph osphate-induced platelet aggregation of human whole blood. Compound 3 also strongly inhibited ristocetin-induced platelet aggregation. Struc tures of these compounds were elucidated by spectroscopic and chemical means.