SELECTIVE ACCESS TO N-ARYL OR N-ALKYL DERIVATIVES OF ISOINDOLO[2,1-B][2,4]BENZO(OR THIENO)DIAZEPINES

Authors
PIGEON P OTHMAN M NETCHITAILO P DECROIX B
Citation
P. Pigeon et al., SELECTIVE ACCESS TO N-ARYL OR N-ALKYL DERIVATIVES OF ISOINDOLO[2,1-B][2,4]BENZO(OR THIENO)DIAZEPINES, Tetrahedron, 54(8), 1998, pp. 1497-1506
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
54
Issue
8
Year of publication
1998
Pages
1497 - 1506
Database
ISI
SICI code
0040-4020(1998)54:8<1497:SATNON>2.0.ZU;2-0
Abstract
N-alkyl isoindolo[2, 1-b][2,4]benzodiazepines 15c were synthesized via an intramolecular N-acyliminium ion-amide reaction, N-aryl derivative s 8c were obtained from an intramolecular acylation of amino acids 6c in acetic anhydride. A generalization of these methodologies is given in the synthesis of the thiophenic analogues 15d and 8d. (C) 1998 Else vier Science Ltd. All rights reserved.