EXPRESSION OF THE NOVEL MITOXANTRONE RESISTANCE-ASSOCIATED GENE MXR7 IN COLORECTAL MALIGNANCIES

It was shown previously that a glypican encoding gene (MXR7/GPC3/OCl-5 ) was associated with mitoxantrone resistance in vitro, This study des cribes and investigation of an association between multidrug resistanc e and MXR7 in surgical cryo-specimens of 51 gastrointestinal tumors, T he mRNA expression levels differ widely according to tumor species, In primary colorectal cancers, the level of MXR7 mRNA expression correla ted loosely with the mRNA expression level of the multidrug-resistance -associated protein (MRP), In colorectal metastases an elevated MXR7 m RNkA expression level was observed when compared to primary colorectal carcinomas.