ORF186 REPRESENTS A NEW MEMBER OF THE NUDIX HYDROLASES, ACTIVE ON ADENOSINE(5')TRIPHOSPHO(5')ADENOSINE, ADP-RIBOSE, AND NADH

Authors
OHANDLEY SF FRICK DN DUNN CA BESSMAN MJ
Citation
Sf. Ohandley et al., ORF186 REPRESENTS A NEW MEMBER OF THE NUDIX HYDROLASES, ACTIVE ON ADENOSINE(5')TRIPHOSPHO(5')ADENOSINE, ADP-RIBOSE, AND NADH, The Journal of biological chemistry, 273(6), 1998, pp. 3192-3197
Citations number
53
Categorie Soggetti
Biology
Journal title
The Journal of biological chemistry → ACNP
ISSN journal
00219258
Volume
273
Issue
6
Year of publication
1998
Pages
3192 - 3197
Database
ISI
SICI code
0021-9258(1998)273:6<3192:ORANMO>2.0.ZU;2-U
Abstract
orf186, a new member of the Nudix hydrolase family of genes, has been cloned and expressed, and the protein has been purified and identified as an enzyme highly specific for compounds of ADP. Its three major su bstrates are adenosine(5') triphospho(5') adenosine, ADP-ribose, and N ADH, all implicated in a variety of cellular regulatory processes, sup porting the notion that the function of the Nudix hydrolases is to mon itor the concentrations of reactive nucleoside diphosphate derivatives and to help modulate their accumulation during cellular metabolism.