DEMONSTRATION OF LESIONS IN TISSUE AFTER INTRAMUSCULAR INJECTION BY DETERMINATION OF CREATINKINASE ACTIVITY IN BLOOD-PLASMA

Local muscle tissue damage by Terramycin-LA(R) (20 mg/kg BM) injected at the neckmuscle was tested with seven pigs prepared with veneous cat heters. Four of the pigs were used as the control group and were treat ed with an intramuscular injection of 0.9 % NaCl-solution into the opp osite neckmuscle later on. The tissue damage was clinically, pathologi cally and enzymatically examined. A significant rise of creatinkinase (CK) in bloodplasma up to 48 hours after intramuscular injection of Te rramycin-LA(R) proves to be a good indicator of local muscle damage. B ased on enzymekinetic calculations it was possible to estimate the amo unt of muscle laesions after intramuscular injection of Terramycin-LA( R) up to 13 9/100 kg BM and of NaCl-solution up to 0,5 g/100 kg BM res pectively. The difference is significant.