URINARY-EXCRETION OF URODILATIN IN HEALTHY-CHILDREN AND CHILDREN WITHRENAL-DISEASE

Citation
T. Seeman et al., URINARY-EXCRETION OF URODILATIN IN HEALTHY-CHILDREN AND CHILDREN WITHRENAL-DISEASE, Pediatric nephrology, 12(1), 1998, pp. 55-59
Citations number
23
Categorie Soggetti
Pediatrics,"Urology & Nephrology
Journal title
Pediatric nephrology
ISSN journal
0931041X → ACNP
Volume
12
Issue
1
Year of publication
1998
Pages
55 - 59
Database
ISI
SICI code
0931-041X(1998)12:1<55:UOUIHA>2.0.ZU;2-T
Abstract
Urodilatin (URO) is a natriuretic peptide isolated from human urine wh ich is thought to be produced by distal tubular cells. We measured uri nary URO excretion in 50 healthy children and 23 children with acute ( ARF), chronic renal failure (CRF), or hereditary tubular disorders, us ing a specific radioimmunoassay. The mean URO excreted in these four g roups was 56, 45, 94, and 121 fmol/min per 1.73 m(2), respectively (di fferences between first three groups not significant). The variation i n URO excretion was larger in patients with kidney disease than in con trols. There were significant correlations between urinary URO and sod ium excretion in controls and CRF, but not in ARF. URO excretion also correlated with urine flow rate in CRF. Although no correlation was fo und between URO excretion and creatinine clearance, urinary URO was in creased in some patients with advanced CRF, which suggests stimulated tubular production to compensate for reduced sodium excretion. In view of the therapeutic potential of URO in renal insufficiency, further s tudy of the renal handling of URO is warranted.