THE RELATIONSHIP OF HELICOBACTER-PYLORI COLONIZATION, THE SERUM PEPSINOGEN-A LEVEL, AND GASTRIC RESECTION

The serum levels of pepsinogen A (PB;A) were measured in patients who underwent various forms of gastric resection to assess whether Helicob acter pylori (HP) colonization has any influence, Included in this stu dy were 48 patients who underwent subtotal gastrectomy for a peptic ul cer (SGPU), 36 who underwent radical subtotal gastrectomy for gastric carcinoma (SGGC), 16 who underwent truncal vagotomy plus antrectomy (T V + AE), 24 with recurrent ulcer (RU) and 27 who underwent total gastr ectomy (TG), The mean serum PGA levels in these five groups and in 40 healthy controls were 49.1 +/- 30.4 ng/ml, 30.0 +/- 14.8 ng/ml, 44.8 /- 21.7 ng/ml, 66.4 +/- 42.8 ng/ml, 8.7 +/- 3.0 ng/ml, and 94.7 +/- 27 .9 ng/ml, respectively. All patients except those with RU showed a dim inished PGA level, The HP colonization rates of the patients who under went partial resection were 45.8%, 22.2%, 50%, and 54.2%, respectively (P < 0.05), Age, gender, smoking, the type of gastroenterostomy, and underlying disease did not exert any influence on the measured PGA lev els, However, higher PGA levels were observed in HP-colonized patients who either underwent SGPU or had RU, We conclude that various forms o f distal gastrectomy, but not RU, elicit an indistinguishable acid sec retory ability while HP colonization is responsible for the higher ser um PGA levels in some patients following peptic ulcer surgery.