PREPARATION OF ALKYL-AMINO[H-2(2)]METHYLPHOSPHINIC AND ARYL-AMINO[H-2(2)]METHYLPHOSPHINIC ACIDS

Authors
BERTEVERRANDO S NIEF F PATOIS C SAVIGNAC P
Citation
S. Berteverrando et al., PREPARATION OF ALKYL-AMINO[H-2(2)]METHYLPHOSPHINIC AND ARYL-AMINO[H-2(2)]METHYLPHOSPHINIC ACIDS, Journal of the Chemical Society. Perkin transactions. I, (16), 1995, pp. 2045-2048
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
16
Year of publication
1995
Pages
2045 - 2048
Database
ISI
SICI code
0300-922X(1995):16<2045:POAAA>2.0.ZU;2-Y
Abstract
Diethyl chloro[H-2(2)]methylphosphonate upon successive treatment with POCl3 and Grignard reagents (RMgX) gave alkyl(chloro[H-2(2)] methyl)p ho sphinates. Phenyl(chloro[H-2(2)]methyl)phosphinate was prepared by deuteriolysis of the alpha-silylated alpha-phosphonylated carbanion 11 with D2O. After conversion into trifluoroethyl phosphinic esters, the alkyl- and phenyl-(chloro[H-2(2)]methyl)phosphinates were converted i nto azides and then reduced and hydrogenated into alkyl- and phenyl-(a mino[H-2(2)]lmethyl)phosphinic acids.