Ag. Deperedo et al., SYNTHESIS AND BIOLOGICAL EVALUATION OF FLAVANONES AND FLAVONES RELATED TO PODOPHYLLOTOXIN, Chemical and Pharmaceutical Bulletin, 46(1), 1998, pp. 79-83
A series of novel flavonoids comprising structural elements present in
the antineoplastic agents podophyllotoxin and etoposide was synthesiz
ed. These oxygen-containing analogues of antiproliferative quinolones
exhibited moderate cytotoxicity towards L1210 and HT-29 cell lines.