SYNTHESIS OF BETA-(SEC-AMINO)ALANINES

Authors
ABE N FUJISAKI F SUMOTO K
Citation
N. Abe et al., SYNTHESIS OF BETA-(SEC-AMINO)ALANINES, Chemical and Pharmaceutical Bulletin, 46(1), 1998, pp. 142-144
Citations number
4
Categorie Soggetti
Chemistry Medicinal",Chemistry,"Pharmacology & Pharmacy
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
46
Issue
1
Year of publication
1998
Pages
142 - 144
Database
ISI
SICI code
0009-2363(1998)46:1<142:SOB>2.0.ZU;2-M
Abstract
Preparation of beta-(sec-amino)alanines (3) by acid hydrolysis of diet hyl (sec-aminomethyl)formamidomalonates (2) was studied. Although high reaction temperature resulted in low yield, low reaction temperature (below 30 degrees C) gave good to excellent yields. The hydrolysis of diethyl formamido(piperidinomethyl)malonate (2a) was followed by H-1-N MR, and a plausible mechanism involving the condensation of ethyl hydr ogen aminomalonate (7) with 1-piperidinemethanol (5) is proposed.