NF00659A(1), NF00659A(2), NF00659A(3), NF00659B-1 AND NF00659B-2, NOVEL ANTITUMOR ANTIBIOTICS PRODUCED BY ASPERGILLUS SP NF-00659 .1. TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL-ACTIVITIES

Five novel cytotoxic antibiotics, NF00659A(1) (1), A(2) (2), A(3) (3), B-1 (4) and B-2 (5) were discovered. They were isolated from a cultur e mycelium of Aspergillus sp. These compounds were proved to have 4,5- seco-tricyclic diterpene alpha-pyrone structure by spectroscopic analy ses. They showed potent antitumor activities against human ovarian car cinoma A2780 and human colorectal adenocarcinoma SW480 cells, but did not show any antimicrobial activities at 1,000 mu g/ml against Gram-po sitive and Gram-negative bacteria, yeasts and fungi.