EXPRESSION OF THYROID-HORMONE RECEPTOR-ALPHA AND BETA-1 MESSENGER-RNAIN HUMAN ENDOTHELIAL-CELLS - THE T3 HORMONE STIMULATES THE SYNTHESIS OF THE MESSENGER-RNA OF THE INTERCELLULAR-ADHESION MOLECULE-1

A study of the effect of the L-3,5,3'-triiodothyronine hormone on the expression of the mRNA of the adhesion molecule ICAM-1 led to the obse rvation that the mRNA level is slightly up-regulated in human umbilica l-cord endothelial cells. To analyze this induction at a molecular lev el, the search of T3 hormone receptors was undertaken. In this paper, we show that ECV 304 endothelial cells express the mRNAs encoding two thyroid hormone receptor isoforms alpha (alpha 1 and alpha 2) and one beta (beta 1) This is, to our knowledge, a first important step toward s the demonstration of the involvement of these receptors in the induc tion of the expression of ICAM-1 by the T3 hormone.